Author: Sanghamitra Kanungo, MD

Purpose: To diagnose, treat and follow-up following treatment with anti VEGF, of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). 

Method: Sixteen eyes of 16 patients were examined by FA, SS-OCT and OCT-A. Central 6×6 scans macular cubes were performed in all. Anti VEGF were injected and repeat OCT and OCTA scans done in every follow up visits to note the regression and for retreatment. Retreatment after 3 loading doses was decided after analyzing the vascular lesion density.

Results: Four weeks after the anti VEGF injection, OCT angiography revealed a progressively smaller vascular lesion and vessel density although the large central trunks of the lesion were unchanged.

Conclusion: Microvascular components can be delineated with precision, suggesting that this technique may be useful for the management and follow up of patients with neovascular AMD in a clinical setting, where FA being an invasive technique cannot be done in every visit.