Martine Mauget-Faÿsse1, Catherine Favard2, Vivien Vasseur1, Kenin Zuber1, Flore DeBats3
1. Rothschild Foundation, Paris, France
2. Odéon Center, Paris, France
3. Pole Vision, Val d’Ouest Clinic, Lyon, France
Agreement of Swept source (SS) optical coherence tomography angiographies (OCT-A) for Polypoidal Choroidal Vasculopathy (PCV) diagnosis and neovascular activity evaluation.
Coscas and al. proposed a « CNV activity criteria grid » for exudative AMD patients. The purpose of this study was to determine the agreement between SS-OCT-A for PCV diagnosis and neovascular activity evaluation according to Coscas CNV activity grid and an original PCV diagnosis and neovascular activity evaluation.
Patients with active or non-active PCV and exudative AMD underwent SS-OCT-A. SS-OCT-A images were obtained using a DRI OCT Triton Swept source OCT. The diagnosis and the neovascular activity of PCV and AMD patients were assessed using multimodal imaging with fluorescein angiography, indocyanine green angiography and spectral domain OCT- B. SS-OCT-A images were analyzed by an expert operator to diagnose whether patients had PCV or AMD and to evaluate their neovascular activity.
Using SS-OCT-A, 13 patients with AMD and 14 patients with PCV were evaluated. There were 92,3% of correct answers among AMD patients and 61,5% of correct answers among PCV patients. The overall agreement, using Cohen’s kappa, between the diagnoses was 0.70 (0.5082-0.8916).
These results demonstrate that Coscas’s CNV activity criteria grid on OCT-A is not applicable to PCV eyes regardless of the level of expertise of the examinator. Currently, OCT-A alone is not able to diagnose efficiently PCV activity.